A Novel Treatment Option for Autism Spectrum Disorder

INDICATION

Autism Spectrum Disorder (ASD)

The autism community urgently needs better therapeutic options. Currently only two drugs are approved to address this condition, and both come with frequent adverse side effects.

Drug Candidate - AJA001 DeFloria™

DEFLORIA is a joint venture between Ajna BioSciences, Charlotte’s Web, and BAT dedicated to developing the first FDA-Approved, full spectrum botanical hemp extract specifically tailored to alleviate the symptoms of Autism Spectrum Disorder.

A Full Spectrum CBD Extract

  • DeFloria Receives Investigational New Drug Application Clearance from FDA for Phase 2 Clinical Trial of AJA001, an Oral Cannabinoid Drug Being Developed for the Treatment of Autism Spectrum Disorder (ASD)

    February 24, 2025

  • DeFloria Announces Positive Results from Phase 1 Trial of AJA001 Being Developed for the Treatment of Autism Spectrum Disorder (ASD)

    Decemeber 12, 2024

  • DeFloria LLC Commences Phase 1 Clinical Program for Innovative Full Spectrum Hemp Botanical Drug

    December 13, 2023

By leveraging Charlotte’s Web’s patented genetics and an optimized formula designed for peak bioavailability, AJA001 has the potential to transform treatment for ASD by providing symptom relief for an enhanced quality of life, paving the way for brighter futures for both patients and families.

  • Leveraging Charlotte’s Web's premium proprietary hemp extracts and Ajna’s proven drug development expertise, DEFLORIA is poised to fulfill its mission with excellence and innovation.

  • Harnessing the therapeutic potential of CBD delivers healing benefits without the psychoactive implications commonly linked to cannabis. This serves as the cornerstone for expansive R&D and future applications.

  • Renowned entrepreneurs with a successful track record in the CBD wellness sector, guided by top-tier thought leaders including Orrin Devinsky, MD., world-renowned pediatric neurologist and lead principal investigator for Epidiolex™, the only FDA-approved CBD drug.

  • Upon FDA approval, DEFLORIA gains first mover advantage fortified by patent protection. Initiated 18 months ago, DEFLORIA’s program is poised to deliver the world’s first oral-systemic botanical drug.

JOINT VENTURE HIGHLIGHTS

A recent study indicates that all three of these component molecules found in AJA001 are likely important in treating ASD in the general population.

ENTOURAGE EFFECT

DEVELOPMENT TIMELINE

LEADERSHIP TEAM & BOARD

  • Jared-Stanley-DeFloria-CEO

    Jared Stanley

    Chief Executive Officer - Co-founder & Board member of Charlotte’s Web with 15+ years experience in cannabis operations.

  • Orrin-Devinksy-MD-Defloria

    Orrin Devinsky, MD

    Chief Medical Advisor - Ajna BioSciences, Director Comprehensive Epilepsy Center at NYU Langone. Formerly lead principal investigator for Epidiolex™.

  • Ryan-Lanier-CSO-Defloria

    Ryan Lanier, PhD

    Chief Scientific Advisor - 20+ years researching CNS compounds including cannabinoids & psychedelics. Expert in pharmaceutical product development from IND-enabling studies through Phase III clinical trials.

  • Marcel-Bonn-Miller-Defloria-Board-Member

    Marcel Bonn-Miller

    Board Member - Chief Scientific Officer - Charlotte’s Web, 20+ years of cannabinoid drug development expertise, including Zynerba Pharmaceuticals and Canopy Growth Corporation.

  • Joel-Stanley-Chairman-Defloria

    Joel Stanley

    Board Chairman - Co-founder Ajna BioSciences Former CEO & Board Chairman of Charlotte’s Web.

  • Donna-Gutterman-Board-Defloria

    Donna Gutterman, PharmD, MBA

    President at Onesta, Inc., 35+ years pharmaceutical industry experience (GSK) in developing, launching and commercialization of medicines in CNS therapeutic area.

  • Bob Judge

    Board Member - 30+ years as CFO and consultant to numerous industries including CBD. Senior manager with KPMG on public and private entities. VP Finance - Ajna Biosciences

  • Stephen-Rogers-Defloria-Board-Member

    Stephen Rogers

    DEFLORIA Board Member, Senior Vice President, General Counsel, and Corporate Secretary at Charlotte’s Web

Join us in leading change and creating hope for millions.

Our groundbreaking work has led us to the cusp of a medical breakthrough, and we invite you to be part of this revolutionary journey.

 

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